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Job Title: Visiting Scientist
Job Number: 1710-10064-VS-01
Organization: IHRC, Inc.
Posted: 11/1/2017
Type: Full-Time
Number of Openings: 1
Location: Silver Spring,  MD    USA
Compensation: Commensurate with qualifications and experience
Position Description:

JOB TITLE: Visiting Scientist

POSITION NUMBER: 1710-10064-VS- 01




TRAVEL:  As required to fulfill the responsibilities of the position

IHRC, Inc. provides scientific, information management, management consulting, bioinformatics, and administrative program support to the Centers for Disease Control and Prevention (CDC) and other Federal and private sector clients.  The successful candidate will be a full-time employee of IHRC, Inc., and will be assigned to the Laboratory of Infection Control, Office of Science and Engineering Laboratories (OSEL), Division of Biology, Chemistry and Material Sciences (DBCMS), at the Food and Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993, to design, develop and optimize sensitive, specific, and robust, in vitro diagnostic assays.


The Visiting Scientist will design, develop and optimize sensitive, specific, and robust, in vitro diagnostic assays that will clearly differentiate between Zika Virus (ZV) and the closely related West Nile Virus (WNV) and Dengue Virus (DV), and can be used in BSL-2 to identify ZV antibodies in infected patients.


  • Develop a Zika sensitive mouse model and Zika reagents for nucleic acid assays and immunoassays

    • Develop a Zika sensitive rodent model
    • Generate Zika specific plasmids and proteins and conduct the immunization of mice and rabbits with Zika proteins
  • Develop Zika specific cell mediated immunoassays
    • Develop a Zika ELISpot assay, conduct bioinformatic analysis of Zika peptides binding with Class 1 MHC of Rhesus Macaque MHC (Mamu) and perform Zika peptide stabilization studies
    • Develop a Zika mimotope library for proteins and identify the cytokine expression in T cells following Zika immunization using a mimotope library
  • Develop Zika Specific humoral immunoassays
    • Develop Zika ELISA and Luminex-based assays, identify immunodominant antibody epitopes using a slide based peptide library, construct Zika plasmids for virus like particles (VLPs) and develop Zika based VLP neutralizing antibody assays using a mimotope library for proteins
  • Author detailed laboratory reports with plots, charts, and tables illustrating the performance of the Zika specific immunoassays
    • Collate, synthesize and interpret data collected and compile into scientific manuscripts suitable for publication



Education and Experience:

  • Ph.D. in immunology, biotechnology, biochemistry, microbiology, molecular biology or a related discipline with 5 years of experience performing research related to the requirements of the position


  • Demonstrated experience with research involving cellular and humoral immunity immunological assays, and small animal handling
  • Suitable training and publications demonstrating the ability to:
    • Identify/generate a Zika sensitive/transgenic rodent model, generate/amplify and purify plasmids and generate antibody responses in mice
    • Utilize bioinformatics software to identify potential immunodominant epitopes, establish flow based Class 1 MHC stability studies, establish a flow cytometric based cytotoxic T cell assay, generate and characterize a mimotope library, and generate tetramers to follow cell mediated responses in mice
    • Employ Luminex technology, identify humoral epitopes using peptides printed on slides, and generate virus like particles (VLPs) for flow based neutralizing assays
    • Write detailed monthly summaries of ongoing projects
  • Excellent writing and documentation skills, and ability to achieve goals with minimal supervision

Desirable :

  • Previous experience developing intracellular cytokine assays and multi-colored flow cytometry based immune assays to measure Zika envelope antigen- specific responses
  • Strong publication record in high impact scientific journals demonstrating sound theoretical and practical knowledge of immunology, cell biology and molecular biology
  • Expertise in developing assays related to antigen-specific antibody detection and quantification in serum and mucosal samples
  • Experience and expertise working with multiple animal models using a variety of techniques to study the cellular and humoral immune response
  • Experience and expertise in the authoring and authorization of Institutional Animal Care and Use Committee (IACUC) protocols

Language Skills:

  • The candidate must possess excellent oral and written communication skills in English   


  • Must be United States citizen or permanent resident or have authorization for employment in the United States

SALARY:  Commensurate with qualifications and experience

To apply for this position:

  • If you are viewing this position on the IHRC Career Center, please click on the "Apply Now" button.  
  • If you are viewing this position on a site other than the IHRC Career Center, you may use the “click to apply” link, or you may apply by visiting our Career Center and searching for the position number listed at the top of this position description.  
  • To view all of our open positions, and to apply to those positions in which you may be interested, please visit our Career Center, which can also be reached by visiting and clicking on the “View Opportunities” link.

IHRC, INC. IS AN EQUAL OPPORTUNITY AND AFFIRMATIVE ACTION EMPLOYER.  It is the policy of IHRC, Inc. to provide equal employment opportunities without regard to race, color, religion, citizenship, age, sex, sexual orientation, gender identity, national origin, ancestry, genetic information, veteran or disability status, or any other characteristic protected by applicable Federal, State or Local law, and to take affirmative action in accordance with applicable laws and Executive Orders.

Organization Description:

IHRC, Inc. is an international consulting and professional services corporation, located in Atlanta, Georgia, USA. IHRC is a minority woman-owned small business and participates in the 8(a) business development program of the U.S. Small Business Administration. We assist our clients in accomplishing their missions and objectives in a timely and cost-effective manner, and we strive exceed our clients’ expectations.

Closing Date: 2/1/2018
Desired Starting Date:
Contact Name: HUMAN RESOURCES,  Visiting Scientist
Contact Location: 2 Ravinia Dr. Suite 1200

Atlanta   GA  30346
United States
Contact Location: 2 Ravinia Dr. Suite 1200
  Atlanta   GA  30346
  United States
Contact Phone:  
Contact Fax:
Contact Email:
Web Address:
How to Apply:

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Additional Information:

Web Site Delete Date: 12/1/2017